.hattr-manifestations-wrapper .animation-footnote {
    color: #000000;
    font-size: 14px;
    font-family: "Britanica-Bold";
    line-height: 16px;
    margin-left: 29px;
    margin-bottom: 0px;
    padding-bottom: 24px;
}
#disease-overview .mixed-phenotype h2 {
    max-width: 1059px;
}


.hattr-manifestations .content-wrapper .content ul {
    display: none;
}

.hattr-manifestations {
    display: flex;
    justify-content: flex-start;
}
.clinical-txt {
    max-width: 1160px;
    margin: 0 auto;
    color: #006838;
    font-size: 20px;
    padding: 6px 0 32px;
    font-family: 'Lexend', sans-serif;
    font-weight: 700;
    letter-spacing: -0.3px;
}
.small-txt {
    margin-bottom: 40px !important;
    font: normal normal normal 18px/20px Britanica;
    color: #000;
}
.img-phenotype {
    margin-bottom: 16px;
}


#disease-overview  #symptoms-associated{
    margin-bottom: 30px;
}

.hattr-manifestations .content-wrapper .content {
    display: flex;
    align-items: center;
    justify-content: flex-start;
    margin-bottom: 17px;
    position: relative;
    padding-left: 20px;
    padding-right: 34px;
    width: 426px;
    cursor: pointer;
    background: #EFEFEF;
    border-radius: 5px;
}

.neuropathy-active .hattr-manifestations .content-wrapper .content.neuropathy,
.heart-active .hattr-manifestations .content-wrapper .content.heart,
.stomach-issues-active .hattr-manifestations .content-wrapper .content.stomach-issues,
.nephropathy-active .hattr-manifestations .content-wrapper .content.nephropathy,
.painful-tingling-active .hattr-manifestations .content-wrapper .content.painful-tingling,
.musculoskeletal-active .hattr-manifestations .content-wrapper .content.musculoskeletal

{
    border-radius: 5px;
    background: #FFF;
    box-shadow: 0px 0px 4px 0px rgba(0, 0, 0, 0.25);
}

.hattr-manifestations .image {
    position: relative;
}
.hattr-manifestations .image ul {
    position: absolute;
    top: 7%;
    left: 50%;
    overflow: visible;
    text-wrap: nowrap;
    max-width: 425px;
    width: 425px;
    padding: 10px 32px 16px 140px;
    background: #F8F8F9 0% 0% no-repeat padding-box;
    box-shadow: 0px 2px 6px #17090348;
    z-index: -1;
    clip-path: polygon(0 0, 100% 0, 92% 100%, 0% 100%);
    display: none;
    max-height: 140px;
}
.hattr-manifestations-wrapper .hattr-manifestations .image img {
    display: none;
}

#disease-overview .hattr-manifestations-wrapper.painful-tingling-active .image img.man-1,
#disease-overview .hattr-manifestations-wrapper.neuropathy-active .image img.man-2, 
#disease-overview .hattr-manifestations-wrapper.stomach-issues-active .image img.man-3,
 #disease-overview .hattr-manifestations-wrapper.musculoskeletal-active .image img.man-4,
 #disease-overview .hattr-manifestations-wrapper.heart-active .image img.man-5,
  #disease-overview .hattr-manifestations-wrapper.nephropathy-active .image img.man-6
   
     {
    display: block;
    max-width: 209px;
}
#disease-overview .hattr-manifestations ul li {
    font-size: 16px;
    line-height: 1;
    margin-bottom: -3px;
    font-family: 'Britanica-Regular'; 
    color: #1C1C1C;
    text-indent: -5px;
    padding-left: 5px;
}
#disease-overview .hattr-manifestations ul li:not(:last-child) {padding-bottom: 5px;}
.hattr-manifestations ul li::before {  
    content: "\2022";
    color: #F26522;
    font-weight: bold;   
    font-size: 22px;
    position: relative;    
    left: -5px;
    top: 2px;

    
}
.hattr-manifestations .content-wrapper .content .content-image {
    max-width: 100px;
}
.hattr-manifestations-wrapper.neuropathy-active ul.neuropathy-description, 
.hattr-manifestations-wrapper.heart-active ul.heart-description, 
.hattr-manifestations-wrapper.stomach-issues-active ul.stomach-issues-description, .hattr-manifestations-wrapper.nephropathy-active ul.nephropathy-description, .hattr-manifestations-wrapper.painful-tingling-active ul.painful-tingling-description-description, .hattr-manifestations-wrapper.musculoskeletal-active ul.musculoskeletal-description {
    position: absolute;
    display: block;    
    width: 280px;
    z-index: 2;
    background: url(/content/dam/intelligentcontent/brands/wainuahcp/us/en/phase1/images/white-bg.png);
    overflow: visible;    
    border-radius: 5px;
    top: -7px;
    box-shadow: none;
    background-size: 100% 100%;
    background-repeat: no-repeat;
    height: 112px;
    display: flex;
    flex-direction: column;    
    justify-content: center;
    padding-left: 44px;
    left: 102%;
    padding-bottom: 9px;
}
.hattr-manifestations .content-wrapper .content .content-image img {
    min-width: 75px;
    height: 100px;
}
.hattr-manifestations-wrapper .hattr-manifestations .image {
    max-width: 29.3%;
    margin-left: 265px;
    margin-top: 0;
    z-index: 1;
    width: 100%;
}
.hattr-manifestations-wrapper .hattr-manifestations .content-image img.active {
    display: none;
}
.hattr-manifestations .content-wrapper .content .content-description {
    padding-left: 20px;
}
.hattr-manifestations .content-wrapper .content .content-description ul {
    display: none;
}
.hattr-manifestations-wrapper.neuropathy-active .neuropathy img {
    display: none;
}
.hattr-manifestations-wrapper.neuropathy-active .neuropathy img.active, .hattr-manifestations-wrapper.neuropathy-active .neuropathy-description {
    display: block;
}
.hattr-manifestations-wrapper.painful-tingling-active .painful-tingling img {
    display: none;
}
.hattr-manifestations-wrapper.painful-tingling-active .painful-tingling img.active, .hattr-manifestations-wrapper.painful-tingling-active .painful-tingling-description-description {
    display: block;
}
.hattr-manifestations-wrapper.musculoskeletal-active .musculoskeletal img {
    display: none;
}
.hattr-manifestations-wrapper.musculoskeletal-active .musculoskeletal img.active, .hattr-manifestations-wrapper.musculoskeletal-active .musculoskeletal-description {
    display: block;
}
.hattr-manifestations-wrapper.nephropathy-active .nephropathy img {
    display: none;
}
.hattr-manifestations-wrapper.nephropathy-active .nephropathy img.active, .hattr-manifestations-wrapper.nephropathy-active .nephropathy-description {
    display: block;
}
.hattr-manifestations-wrapper.heart-active .heart img {
    display: none;
}
.hattr-manifestations-wrapper.heart-active .heart img.active, .hattr-manifestations-wrapper.heart-active .heart-description {
    display: block;
}
.hattr-manifestations-wrapper.stomach-issues-active .stomach-issues img {
    display: none;
}
.hattr-manifestations-wrapper.stomach-issues-active .stomach-issues img.active, .hattr-manifestations-wrapper.stomach-issues-active .stomach-issues-description {
    display: block;
}
#disease-overview .hattr-manifestations-wrapper h3, #disease-overview .hattr-manifestations-wrapper h3, #disease-overview .hattr-manifestations-wrapper h3, #disease-overview .hattr-manifestations-wrapper h3, #disease-overview .hattr-manifestations-wrapper h3, #disease-overview .hattr-manifestations-wrapper h3 {
    color: #000;
    font-size: 20px;
    font-weight: 400;
}
#disease-overview .hattr-manifestations-wrapper.neuropathy-active .neuropathy h3, #disease-overview .hattr-manifestations-wrapper.painful-tingling-active .painful-tingling h3, #disease-overview .hattr-manifestations-wrapper.musculoskeletal-active .musculoskeletal h3, #disease-overview .hattr-manifestations-wrapper.brain-active .brain h3, #disease-overview .hattr-manifestations-wrapper.heart-active .heart h3, #disease-overview .hattr-manifestations-wrapper.nephropathy-active .nephropathy h3, #disease-overview .hattr-manifestations-wrapper.stomach-issues-active .stomach-issues h3 {
    color: #006838;
    font-family: 'Lexend';
    font-weight: 700;
}
#disease-overview .hattr-manifestations-wrapper .heading-wrapper h3 sup {
    font-size: 60%;
    vertical-align: super;
    line-height: normal;
}



#disease-overview .hattr-manifestations-wrapper .heading-wrapper h3 {
    font-size: 22px;
    line-height: 38px;
    color: white;
    padding: 7px 0 11px 24px;
}
#disease-overview .hattr-manifestations-wrapper .heading-wrapper h3 span {
    font-size: 70%;
}
#disease-overview .hattr-manifestations-wrapper .heading-wrapper {
    background: url(/content/dam/intelligentcontent/brands/wainuahcp/us/en/phase1/images/desktop/bar_2x.png);
    width: 100%;
    margin: auto;
    background-size: 100% 100%;
    background-repeat: no-repeat;
}
#disease-overview .mobilebottomimage {
    display: none;
}
.hattr-manifestations .image ul.brain-description {
    top: 1%;
}
.hattr-manifestations .image ul.heart-description {
    top: 16%;
    padding-top: 23px;
    padding-left: 118px;
    left: 60%;
}
.hattr-manifestations .image ul.neuropathy-description {
    height: 102px;
    padding-top: 16px;
    padding-left: 130px;
}
.hattr-manifestations .image ul.stomach-issues-description {
    top: 15%;
}
.hattr-manifestations .image ul.musculoskeletal-description {
    top: 63%;
    left: 155px;
    padding-left: 88px;
    max-width: 391px;
    padding-top: 19px;
    padding-bottom: 20px;
}
.hattr-manifestations .image ul.nephropathy-description {
    top: 43%;
    left: 175px;
    padding-left: 88px;
    max-width: 391px;
    padding-top: 19px;
    padding-bottom: 20px;
}
.hattr-manifestations .image ul.painful-tingling-description-description {
    top: 72%;
    padding-left: 64px;
    left: 175px;
    padding-right: 59px;
    width: 395px;
    height: 150px;
    padding-top: 20px;
}
.hattr-manifestations .content-wrapper .mobile-description {
    display: none;
}
.hattr-manifestations .image ul.stomach-issues-description {
    top: 36.5%;
    padding-top: 31px;
    padding-bottom: 31px;
    left: 58%;
}

.mixed-sec{
    display: flex;
    gap: 20px;    
    align-items: center;
}
.mixed-text h2{
    font-size: 20px;
    margin-bottom: 0.5rem 
}
.mixed-text h3{
    font-family: 'Lexend', sans-serif;
    font-weight: 400;
    font-size: 20px;
    color: #1C1C1C;
}

.mixed-text-1{
    color: #004122;
    font-family: "Britanica-Black";
    margin-top: 23px;
    margin-bottom: 23px;
    font-size: 20px;
}

#disease-overview .protein-text-sec .warning-icon{
    width: 32px;
    margin-top: 5px;
}

@media (min-width:320px) and (max-width: 374px) {
    .hattr-manifestations-wrapper.neuropathy-active .content-wrapper ul.neuropathy-description, .hattr-manifestations-wrapper.heart-active .content-wrapper ul.heart-description, .hattr-manifestations-wrapper.stomach-issues-active .content-wrapper ul.stomach-issues-description, .hattr-manifestations-wrapper.nephropathy-active .content-wrapper ul.nephropathy-description, .hattr-manifestations-wrapper.painful-tingling-active .content-wrapper ul.painful-tingling-description-description, .hattr-manifestations-wrapper.musculoskeletal-active .content-wrapper ul.musculoskeletal-description{
        width: 35vw !important;
        top: -82px !important;
    }

    #disease-overview .hattr-manifestations-wrapper.painful-tingling-active .image img.man-1, #disease-overview .hattr-manifestations-wrapper.neuropathy-active .image img.man-2, #disease-overview .hattr-manifestations-wrapper.stomach-issues-active .image img.man-3, #disease-overview .hattr-manifestations-wrapper.musculoskeletal-active .image img.man-4, #disease-overview .hattr-manifestations-wrapper.heart-active .image img.man-5, #disease-overview .hattr-manifestations-wrapper.nephropathy-active .image img.man-6{
        width: 60px;
    height: 190px;
    }

    #disease-overview .hattr-manifestations-wrapper h3{
        font-size: 12px;
    }
    #disease-overview .hattr-manifestations .content-wrapper .content{
        width: 150px;
    }

}


@media (max-width: 767px) {
    
    #disease-overview .disease-icon1,
    #disease-overview .disease-icon2,
    #disease-overview .disease-icon3,
    #disease-overview .disease-icon4,
    #disease-overview .disease-icon5,
    #disease-overview .disease-icon6 {max-width: 100% !important;}

.hattr-manifestations-wrapper .hattr-manifestations .image {margin-left: 0;}
    #disease-overview .hattr-manifestations .content-wrapper .content .content-description {
        padding: 0;
   }
   #disease-overview .hattr-manifestations-wrapper.painful-tingling-active .image img.man-1,
   #disease-overview .hattr-manifestations-wrapper.neuropathy-active .image img.man-2, 
   #disease-overview .hattr-manifestations-wrapper.stomach-issues-active .image img.man-3,
    #disease-overview .hattr-manifestations-wrapper.musculoskeletal-active .image img.man-4,
    #disease-overview .hattr-manifestations-wrapper.heart-active .image img.man-5,
     #disease-overview .hattr-manifestations-wrapper.nephropathy-active .image img.man-6 {
        display: block;
        width: 54%;
        margin: 0 auto;
        max-width: 95px;
        max-height: 290px;
        transform: translate(-5px, 2px);
   }
    #disease-overview .hattr-manifestations-wrapper .heading-wrapper {
        width: 93.4%;
        margin: auto;
        margin-left: 12px;
   }
    .hattr-manifestations .content-wrapper .content {
        gap: 13px;
        padding-left: 0;
   }
    #disease-overview .hattr-manifestations .image ul {
        display: none;
   }
    #disease-overview .hattr-manifestations .content-wrapper .content .content-description ul {
        display: block;
        padding-left: 14px;
      
   }
    #disease-overview .hattr-manifestations .content-wrapper .content .content-description ul li {
        font-size: 16px;
        line-height: 18px;
        margin-bottom: 5px;
        font-family: 'Britanica-Regular';
   }
    #disease-overview .hattr-manifestations .content-wrapper .content .content-description {
        padding: 0;
   }
    #disease-overview .hattr-manifestations .image {
        max-width: 48%;
   }
    #disease-overview .hattr-manifestations .content-wrapper .content .content-image {
        max-width: 80px;
   }
    #disease-overview .hattr-manifestations-wrapper h3 {
        font-size: 12px;
        line-height: normal;
        margin-bottom: 0;
        padding: 0;
        font-weight: 400;
   }
    #disease-overview .hattr-manifestations-wrapper h3 sup {
        white-space: nowrap;
        font-size: 65%;
    }

    #disease-overview .hattr-manifestations-wrapper .heading-wrapper h3 {
        font-size: 18px;
        line-height: 15px !important;
        margin-bottom: 10px;
   }
    .hattr-manifestations .content-wrapper .content {
        gap: 10px;
   }
    .hattr-manifestations {
        display: flex;
        justify-content: space-evenly;
        flex-direction: row;
        gap: 12px;
        max-width: 100%;        
   }
}


@media (max-width: 991.5px) {
    
    #disease-overview .subpage-topBanner-content h1{line-height: 28px;}
     

    #disease-overview .hattr-manifestations .content-wrapper .content{
        width: 164px;
    }
    #disease-overview .footnote-new {
        padding-top: 20px;
        padding-left: 10px;
        padding-right: 12px;
    }

   .protein-text-sec{
        margin-bottom: 32px;
    }
   .mixed-text p{
        font-size: 18px;
        padding-right: 70px;
    }
   
    .mixed-text h2{padding-right: 21px;}

    #disease-overview .mixed-text h3{font-size: 18px;padding-right: 75px;}
   
    .mixed-sec{gap: 15px;align-items: flex-start;}
    .mixed-sec .warning-icon{
        flex: 0 0 48px;    
    } 
    .mixed-sec .warning-icon img{
        width: 48px;
        height: 42px;
    }

   #disease-overview .diagramBox-title{min-height: 48px;}

   #disease-overview .diagramBox-content{
    padding: 35px 5px 4px 8px;
    margin-bottom: 10px;
   }

   #disease-overview .hattr-manifestations ul li{
    font-size: 14px;
   }

   .mixed-text-1{
    margin-top: 23px;
    margin-bottom: 23px;
    padding-right: 22px;
   }

   
    #disease-overview  #symptoms-associated{
        margin-bottom: 40px;
    }

    #disease-overview  #symptoms-associated #footnotes ol li:nth-of-type(2){padding: 20px 0 2px;}

   .hattr-manifestations .content-wrapper .mobile-description {
        display: block;
    }
    #disease-overview .hattr-manifestations-wrapper.neuropathy-active .neuropathy::before, #disease-overview .hattr-manifestations-wrapper.painful-tingling-active .painful-tingling::before, #disease-overview .hattr-manifestations-wrapper.musculoskeletal-active .musculoskeletal::before, #disease-overview .hattr-manifestations-wrapper.brain-active .brain::before, #disease-overview .hattr-manifestations-wrapper.heart-active .heart::before, #disease-overview .hattr-manifestations-wrapper.nephropathy-active .nephropathy::before, #disease-overview .hattr-manifestations-wrapper.stomach-issues-active .stomach-issues::before {
        content: "";
        width: 5px;
        height: 60px;
        position: absolute;
        left: 0px;
        background: transparent linear-gradient(5deg, #F26522 0%, #FFEF44 100%) 0% 0% no-repeat padding-box;
        border-radius: 5px 0 0 5px;
   }
    .hattr-manifestations .content-wrapper {
        position: relative;
   }
    .hattr-manifestations .content-wrapper .mobile-description {
        position: absolute;
        left: 100%;
        bottom: 41%;
   }
    #disease-overview .footnote-new-sec {
        padding-left: 10px;
        padding-right: 15px;
        margin-top: 16px;
   }
    #disease-overview .dis-sideeff-section {
        background: none;
   }
   
    #disease-overview .dis-sideeff-section {
        flex-flow: column;
   }
    
    #disease-overview #footnode-container p.wain-footnt-ptext sup {
        vertical-align: 4px;
   }
    #disease-overview #footnode-container p.wain-footnt-ptext:nth-child(4) {
        margin-top: 10px;
   }
    #disease-overview .hattr-manifestations .content-wrapper .content .content-image {
        display: block;
        max-width: 100%;
        flex: 0.45;
   }
   #disease-overview .hattr-manifestations .content-wrapper .content .content-description {
        flex: 1;
   }
    .hattr-manifestations-wrapper.neuropathy-active .content-wrapper .content ul.neuropathy-description, .hattr-manifestations-wrapper.heart-active .content-wrapper .content ul.heart-description, .hattr-manifestations-wrapper.stomach-issues-active .content-wrapper .content ul.stomach-issues-description, .hattr-manifestations-wrapper.nephropathy-active .content-wrapper .content ul.nephropathy-description, .hattr-manifestations-wrapper.painful-tingling-active .content-wrapper .content ul.painful-tingling-description-description, .hattr-manifestations-wrapper.musculoskeletal-active .content-wrapper .content ul.musculoskeletal-description {
        display: none;
   }
    .green-gradient-btn {
        margin: 15px auto 35px auto;
   }
 
  
    #disease-overview .mixed-phenotype {
        width: 100%;
   }
    #disease-overview .disease-icon1 {
        width: 80px;
        height: auto;
        max-width: 85%;
        min-width: unset;
   }
    #disease-overview .disease-icon3 {
        width: 80px;
        height: auto;
        min-width: unset;
        max-width: 85%;
   }
    #disease-overview .disease-icon2 {
        margin-bottom: 0;
        width: 80px;
        height: auto;
        min-width: unset;
        max-width: 91%;
   }
    #disease-overview .disease-icon4 {
        width: 80px;
        height: auto;
        max-width: 85%;
        min-width: unset;
   }
    #disease-overview .disease-icon5 {
        width: 80px;
        height: auto;
        max-width: 85%;
        min-width: unset;
   }
    #disease-overview .disease-icon6 {
        width: 80px;
        height: auto;
        max-width: 80%;
        min-width: unset;
   }
    .hattr-manifestations-wrapper .hattr-manifestations .image img.mobile-only {
        display: block;
   }
    .hattr-manifestations .content-wrapper .mobile-description ul {
        display: none;
   }
    .hattr-manifestations-wrapper.neuropathy-active .content-wrapper ul.neuropathy-description, .hattr-manifestations-wrapper.heart-active .content-wrapper ul.heart-description, .hattr-manifestations-wrapper.stomach-issues-active .content-wrapper ul.stomach-issues-description, .hattr-manifestations-wrapper.nephropathy-active .content-wrapper ul.nephropathy-description, .hattr-manifestations-wrapper.painful-tingling-active .content-wrapper ul.painful-tingling-description-description, .hattr-manifestations-wrapper.musculoskeletal-active .content-wrapper ul.musculoskeletal-description {
        position: absolute;
        display: block;
        left: 103%;
        width: 174px;
        z-index: 2;
        background: transparent;
        overflow: visible;
        padding: 18px 0px 18px 16px;
        border-radius: 5px;
        top: 2px;
        box-shadow: none;
        background-size: 100% 100%;
        background-repeat: no-repeat;
        height: auto;
   }
    #disease-overview .hattr-manifestations .content-wrapper .content {
        margin-right: 0;
        margin-left: 0;
        max-width: 100%;
        width: 166px;
        padding: 0px 12px 0px 5px;
        height: 60px;
        margin-bottom: 16px;
        gap: 8px;
   }
   #disease-overview .hattr-manifestations .content-wrapper .content.neuropathy {
        padding-left: 8px;
    }

    #disease-overview .hattr-manifestations-wrapper .heading-wrapper {
        background: url(/content/dam/intelligentcontent/brands/wainuahcp/us/en/phase1/images/mobile/Path%2025679.svg);
        width: 100%;
        margin: auto;
      
        background-repeat: no-repeat;
        background: #006838;
        clip-path: polygon(0 0, 100% 0%, 92% 100%, 0% 100%);
        border-image: linear-gradient(90deg, #FFEF44 0%, #F26522 100%) 0 0 1 0;
        border-width: 0 0 8px 0;
        border-style: solid;
   }
    #disease-overview .hattr-manifestations-wrapper .heading-wrapper .mobilebottomimage img {
        margin-bottom: -2px;
   }
    #disease-overview .hattr-manifestations-wrapper .heading-wrapper h3 {
        padding-top: 9px;
        padding-bottom: 6px;
        padding-left: 15px;
        margin-bottom: 0px !important;
   }
    

}




@media (min-width:768px) and (max-width: 991.5px) {
    .hattr-manifestations-wrapper .hattr-manifestations .image{margin-left: 0;}

    #disease-overview .hattr-manifestations .content-wrapper .content {
        margin-right: 0;
        margin-left: 0;
        max-width: 100%;
        padding: 0px 12px;
        height: 90px;
        margin-bottom: 10px;
        width: auto;
   }
    #disease-overview .hattr-manifestations-wrapper.neuropathy-active .neuropathy::before, #disease-overview .hattr-manifestations-wrapper.painful-tingling-active .painful-tingling::before, #disease-overview .hattr-manifestations-wrapper.musculoskeletal-active .musculoskeletal::before, #disease-overview .hattr-manifestations-wrapper.brain-active .brain::before, #disease-overview .hattr-manifestations-wrapper.heart-active .heart::before, #disease-overview .hattr-manifestations-wrapper.nephropathy-active .nephropathy::before, #disease-overview .hattr-manifestations-wrapper.stomach-issues-active .stomach-issues::before {
        content: "";
        width: 9px;
        height: 90px;
        position: absolute;
        left: 0px;
        background: transparent linear-gradient(5deg, #F26522 0%, #FFEF44 100%) 0% 0% no-repeat padding-box;
        border-radius: 5px 0 0 5px;
   }
   #disease-overview .hattr-manifestations-wrapper.painful-tingling-active .image img.man-1,
   #disease-overview .hattr-manifestations-wrapper.neuropathy-active .image img.man-2, 
   #disease-overview .hattr-manifestations-wrapper.stomach-issues-active .image img.man-3,
    #disease-overview .hattr-manifestations-wrapper.musculoskeletal-active .image img.man-4,
    #disease-overview .hattr-manifestations-wrapper.heart-active .image img.man-5,
     #disease-overview .hattr-manifestations-wrapper.nephropathy-active .image img.man-6 {
        display: block;
        width: 55%;
        margin: 0 auto;
        max-height: 400px;
        max-width: 125px;
   }
    #disease-overview .hattr-manifestations .image ul {
        display: none;
   }
    #disease-overview .hattr-manifestations .content-wrapper .content .content-description ul {
        display: block;
        padding-left: 20px;
   }
    #disease-overview .hattr-manifestations .content-wrapper .content .content-image {
        max-width: 80px;
   }
    #disease-overview .hattr-manifestations-wrapper h3 {
        font-size: 18px;
   }
    #disease-overview .hattr-manifestations-wrapper {
        padding: 0 13px;
   }
    #disease-overview .hattr-manifestations {
        display: flex;
        justify-content: space-evenly;
        flex-direction: row;
        gap: 30px;
        padding: 30px 20px 0px;
   }
}



@media (min-width:992px) {
    #disease-overview .diagramBox-content{
        padding: 70px 60px 32px;
        margin-bottom: 32px;
    }

    .protein-text-sec{
        margin-bottom: 30px;
       }
       
    .protein-text h2{
        width: 102%;
    }
    #disease-overview .subpage-topBanner{
        height: unset;
    }

    .hattr-manifestations-wrapper.heart-active ul.heart-description{
        height: 164px;
    top: -32px;
    }


    #disease-overview .callout.img-left .callout-img{
        max-width: 60vw;
        left: 0;
    }

    #disease-overview  #callout-container .callout.img-left .callout-text{
        padding-left: 15px;
    }


    #disease-overview .hattr-manifestations-wrapper.neuropathy-active .neuropathy::before, #disease-overview .hattr-manifestations-wrapper.painful-tingling-active .painful-tingling::before, #disease-overview .hattr-manifestations-wrapper.musculoskeletal-active .musculoskeletal::before, #disease-overview .hattr-manifestations-wrapper.brain-active .brain::before, #disease-overview .hattr-manifestations-wrapper.heart-active .heart::before, #disease-overview .hattr-manifestations-wrapper.nephropathy-active .nephropathy::before, #disease-overview .hattr-manifestations-wrapper.stomach-issues-active .stomach-issues::before {
        content: "";
        width: 9px;
        height: 100px;
        position: absolute;
        left: 0px;
        background: transparent linear-gradient(5deg, #F26522 0%, #FFEF44 100%) 0% 0% no-repeat padding-box;
        border-radius: 5px 0 0 5px;
   }
    #disease-overview #footnode-container p.wain-footnt-ptext:nth-child(4) {
        margin-top: 10px;
   }
    #disease-overview .subpage-topBanner-image img{height: 180px;}
    #disease-overview .subpage-topBanner-content{max-width: 85%;}
    #disease-overview #symptoms-associated #footnotes ol li:nth-of-type(1){margin-bottom: 8px;}
    #disease-overview #simple-card-columns .simple-card:nth-of-type(1) .card-title h2{max-width: 90%;}
    #disease-overview #simple-card-columns .simple-card:nth-of-type(2) .card-title h2{max-width: 85%;}

    
   #disease-overview .diagramBox-title{min-height: 60px;}

   .hattr-manifestations .content-wrapper .content.neuropathy{padding-right: 25px;}
}

@media (min-width: 992px) and (max-width: 1160px) {
    .hattr-manifestations {
        overflow: hidden;
   }
    .hattr-manifestations .content-wrapper {
        max-width: 43%;
   }
  
    .hattr-manifestations-wrapper .hattr-manifestations .image {
        margin-left: 220px;
   }
   #disease-overview .callout.img-left .callout-img {left: -70px;}
}